Bacteria Biofilm as bio-factory for tissue regeneration
ABSTRACT:
BIOACTION aims at developing a new methodology in implant technology based on functionalized bio-hydrogels that will convert the negative occurrence of biofilm-associated infections, the primary cause of implant infections and failure, into a positive resource. The main goal of BIOACTION is to transform implant-associated bacteria for the programmable production of specific proteins for in vivo cell recruitment and tissue regeneration, exploiting gene sequences loaded on engineered liposomes and phages, bound to hydrogel scaffolds. BIOACTION will develop new biomimetic substrates that can transform biofilm into extracellular matrix for the regeneration of target tissues. It will establish a high versatile technology to be used as injectable materials and implant coatings for periodontal and periimplant infection treatments. The proposed approach will be validated in two clinically relevant animal models: dental implant and permanent transcutaneous bone. BIOACTION, would radically advance the future of infection treatment by revolutionizing the classical approaches leading to the improvement of state of care, health outcomes and to achieve huge socio-economic benefits. The project is strongly interdisciplinary in nature involving expertise biomaterials, synthetic biology, phage and liposome technology, medicine. As a results, this innovative approach will bring the research and knowledge far beyond the current state-of-the-art and will lead, through the planned validation, as proof-of-concept of new materials and technique with a broader application in regenerative medicine. CNR will participate with 2 institutes, Institute of Polymers, Composites and Biomaterials (IPCB) and Institute for Biological Systems (ISB) with expertise in materials science and engineering and liposome technology, respectively. IPCB is responsible for the coordination of the project.
DIPARTIMENTO: DSCTM
AREA PROGETTUALE: Chimica e Tecnologie dei Materiali
ISTITUTO ESECUTORE DEL PROGETTO: IPCB
SEDE IPCB COINVOLTA: SS NAPOLI/PORTICI
ENTE FINANZIATORE: EUROPEAN COMMUNITIES
Call HORIZON-EIC-2022-PATHFINDEROPEN-01
Grant Agreement Number 101098972
Project start/end date 01/04/2023-31/03/2027
Project coordinator: dr. Luigi Ambrosio, CNR-IPCB
CNR-IPCB Representatives
Scientific Responsible for CNR Dr Maria Grazia Raucci
Management Responsible for CNR Ing. Roberta Marzella
CNR-IPCB Team Members
Luigi Ambrosio, Roberta Marzella, Maria Grazia Raucci, Alessandra Soriente, Giovanna Gomez d’Ayala, Alfredo Ronca, Michele Guerrini, Mariarosaria Bonetti
CONSORTIUM
Coordinator CNR CONSIGLIO NAZIONALE DELLE RICERCHE IT;
Beneficiaries UPO UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE (IT); ULIEGE UNIVERSITE DE LIEGE (BE); IBEC-CERCA FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA (ES); FERENTIS UAB (LT); IN SRL IMPRESA SOCIALE (IT)
Associated Partner ARI AO-FORSCHUNGSINSTITUT DAVOS CH 994047853
WEBSITE https://bioaction.eu/
