Three Dimensional brain in vitro models via electrofluidodynamics

BRIEF DESCRIPTION:

The use of cell cultures grown on two-dimensional (2D) substrates has allowed a significant advancement of knowledge in Neuroscience. However, 2D cell cultures force cells to grow as an artificial monolayer and, consequently, to express morphologies and functionalities different from those observed in neural cells in vivo. Nano-structured interfaces and biomaterials can be optimized for the implementation of in vitro 3D models in which the molecular and functional characteristics of cells in vitro closely resemble those they express in vivo. 3DNEUROGLIA is a joint proposal for a project with two CNR teams (CNR-IPCB and CNR -ISOF) which aims to implement customized micro / nanostructured platforms to define a valid in vitro 3D model that allows studying functions and interactions of neural cells in vitro into a physiologically-like environment similar to that observed in vivo.

KEYWORDS: Electro Fluid Dynamics; Astrocytes; Brain

DIPARTIMENTO: DSCTM

AREA PROGETTUALE: Chimica e Tecnologie dei Materiali

ISTITUTO ESECUTORE DEL PROGETTO: IPCB

SEDE IPCB COINVOLTA: SS NAPOLI/PORTICI

ENTE FINANZIATORE: AFOSR

DURATA: 01/08/2018 – 31/07/2022

SCIENTIFIC REFERENT FOR IPCB: Vincenzo Guarino

IPCB TEAM MEMBERS: Iriczalli Cruz Maya, Luigi Ambrosio

 

PARTNER: CNR (ISOF)

WEB:

https://www.afrl.af.mil/AFOSR/
https://www.facebook.com/afosr/

CONTATTI:

Vincenzo Guarino, vincenzo.guarino(-at-)cnr.it